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Gastroesophageal Reflux Disease and Posterior Laryngitis

The purpose of this study is to determine if treatment with a medication that reduces stomach acid affects symptoms that appear to arise from the throat. It has been suggested that symptoms such as chronic cough and hoarseness are related to gastroesophageal reflux disease (GERD). Patients develop posterior laryngitis due to repeated laryngeal acid exposure. We will evaluate patients with posterior laryngitis due to GERD.  During the study, patients will receive treatment with omeprazole or a placebo ("sugar pill") twice a day and be followed for three months. 

 
Sleep and Gastroesophageal Reflux Disease

These studies look at the effect of antireflux treatment on improving sleep in patients with GERD. Two studies evaluate the relationship between sleep abnormalities and the presence of GERD. In one study patients will be admitted to a sleep lab for evaluation. A correlation between patients' quality of sleep and reported symptoms of GERD will be determined. In another study patients will receive medication or placebo to treat their GERD for two months, symptoms will be compared. At the end of the 2 month treatment period sleep quality will be reevaluated. 

 
Non-Erosive Reflux Disease

Several studies looking at patients with classic heartburn symptoms but without any evidence of esophageal inflammation. Various studies evaluate symptoms and acid exposure profiles.

 
Functional Heartburn

A study targeting a group of patients with GERD who do not have abnormal esophageal acid or inflammation. Patients will undergo a comprehensive evaluation for symptoms including endoscopy, assessment of acid exposure and questionnaires that will evaluate their symptoms.

 

Information Request 

If you would like more information about a particular study, please send an electronic message to: giresearch@mindspring.com - be sure to include the name of the study you are interested in and contact information.

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