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Barrett's Esophagus

This is a study of the overall frequency of the development of adenocarcinoma of the esophagus in patients with Barrett's esophagus. Patients with documented Barrett's esophagus are followed with regular interval endoscopy and biopsy. The effort is to better define the incidence of adenocarcinoma of the esophagus and the specific risk factors for this cancer. Special biopsies are taken at each endoscopy in an effort to identify markers that will help us to predict more accurately the risk of an individual for the development of cancer.

Reversal of Barrett's Esophagus (Multipolar Electrocoagulation vs. Argon Plasma Coagulation)

In this study a high dose acid blocking agent is provided to the patient and patients are then randomized to two different types of endoscopic therapy to eliminate their Barrett's esophagus. One therapy is called multipolar electrocoagulation (MPEC) - cauterizing the esophagus. The other therapy is argon plasma coagulation (APC) - another form of heat injury to the esophagus. Both of these methods have been documented to be capable of eliminating Barrett's esophagus. The purpose of this study is to see which method is more effective, can be achieved in fewer treatment sessions and has fewer side effects.

Chemoprevention of Progression to Neoplasia in Barrett's Esophagus

Within the next year a randomized study will be initiated comparing a COX-2 selective nonsteroidal agent with placebo accompanied by acid suppression with a proton pump inhitibor. The goal will be to see the impact on a panel of biomarkers predicting the progression of neoplasia.


Information Request 

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